Recent Developments in Targeted Drug Delivery System for Crossing Blood- Brain Barrier: a Review
نویسندگان
چکیده
Targeted drug delivery systems have been used to deliver drugs in the disease sites of the body. This may reduce potential side effects of drugs and improve their therapeutic effects. Development of brain targeting drug delivery system help in the treatment of disorders related to brain. The most challenging research topic in pharmaceutical sciences is brain targeting drug delivery system. Most of the drugs do not reach brain effectively because of presence of Blood-Brain Barrier (BBB). There are various strategic approaches that have been proposed for brain drug delivery system. There is requirement of optimization balance among the physicochemical and pharmacokinetic properties of Central Nervous System (CNS) acting drugs, to make them penetrable through BBB and show excellent biological activities. This review article overviews the recent researches in the field of strategies to target brain.
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